Optimisation of stroke prevention for dialysis patients

The anticoagulants currently used to prevent strokes in dialysis patients with atrial fibrillation do not provide adequate protection for this group. This is the finding of a study led by Oliver Konigsbrugge and Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital, which was conducted in collaboration with seven dialysis centers in Vienna.,

Optimisation of stroke prevention for dialysis patients
Graphs of cumulative probability of event occurrence according to anticoagulation for (A) composite of stroke transient ischemic attack and systemic embolism, (B) major bleeding, (C) composite major adverse cardiovascular outcome, and (D) net clinical benefit or harm. Credit: DOI: 10.1111/jth.15508

The anticoagulants currently used to prevent strokes in dialysis patients with atrial fibrillation do not provide adequate protection for this group. This is the finding of a study led by Oliver Konigsbrugge and Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital, which was conducted in collaboration with seven dialysis centers in Vienna.

People with , an often associated with an excessively rapid or slow heart rate, have a greatly increased risk of . The VIVALDI study (Vienna investigation of atrial fibrillation and thromboembolism in patients with atrial fibrillation on hemodialysis), led by Oliver Konigsbrugge and Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital, highlights the need for action to prevent strokes in .

“The proportion of patients with atrial fibrillation is particularly high among hemodialysis patients, being in excess of 25%. Strokes and other contribute significantly to mortality,” explains Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital. “Analysis of cardiovascular events that occurred during the observation period showed that, contrary to expectations, those patients who received anticoagulation treatment with the vitamin K antagonist phenprocoumon showed no benefit in terms of a reducing strokes but did have a higher rate of major bleeding.”

The VIVALDI study was conducted in collaboration with seven dialysis centers in Vienna. A cohort of 625 hemodialysis patients was observed over a maximum period of 45 months. The incidence of thromboembolic events (strokes and systemic embolisms) was 4.8% per year in patients with atrial fibrillation. 8.4% of patients a year suffered major bleeding. “The high overall rate of thromboembolic complications confirms the need for action to provide hemodialysis patients with anticoagulation therapy that is equally effective in preventing strokes and other thromboembolic complications and safe to administer in terms of bleeding risk,” says Ay.

Stroke prevention in atrial fibrillation is well researched among the general population. Based on study results, medication with drugs from the class of direct oral anticoagulants (DOAC) has been established as effective for several years now. This type of medication has so far been withheld from patients with permanent kidney failure and requiring dialysis due to a lack of relevant studies. Currently, only drugs from the class of vitamin K antagonists are approved as oral anticoagulants for hemodialysis patients in German-speaking countries. Clinical trials are currently ongoing into the use of direct oral anticoagulants (DOAC) in hemodialysis patients. “It would appear that there is a need to improve current clinical practice for preventing strokes in hemodialysis patients. We therefore eagerly await the results of the clinical trial,” says Ay.


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More information:
Oliver Konigsbrugge et al, Anticoagulation use and the risk of stroke and major bleeding in patients on hemodialysis: From the VIVALDI, a population-based prospective cohort study, Journal of Thrombosis and Haemostasis (2021). DOI: 10.1111/jth.15508

Provided by
Medical University of Vienna

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