Weight loss may repair the brain after stroke in diabetes

People with type 2 diabetes have an increased risk of stroke and slower recovery from it. Now, researchers at Karolinska Institutet have shown that neurological recovery from stroke is significantly improved in mice with obesity and diabetes who achieve weight loss to the extent that glucose metabolism returns to normal levels. The results are published in the scientific journal Cardiovascular Diabetology and may have clinical relevance for stroke rehabilitation in type 2 diabetes.,

Weight loss may repair the brain after stroke in diabetes
Dietary change leading to weight loss normalizes T2D-induced neuroinflammatory changes after tMCAO. a Iba-1 expression in striatum after sham surgery. b Iba-1 expression in contralateral striatum after tMCAO surgery. c Iba-1 expression in ipsilateral striatum after tMCAO surgery. d CD68 expression in ipsilateral striatum after tMCAO surgery. Data are presented as mean ? SD. Brown-Forsythe and Welch ANOVA followed by two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli was used for all analyses. * Denotes p <? 0.05, ** denotes p <? 0.01. e Representative images of Iba-1 staining in ipsilateral striatum after tMCAO (left panel), with corresponding examples of thresholded images (right panel). Scale bar: 250 um. f Representative images of CD68 staining in ipsilateral striatum after tMCAO. Black arrows indicate CD68+ cells and red arrows indicate hematoxylin+ cells. Scale bar: 25 um. Group sizes: a non-T2D n = 5, T2D/Ob n = 4, T2D/WL n = 4. b, c Non-T2D n = 7, T2D/Ob n = 5, T2D/WL n = 6. d Non-T2D n = 6, T2D/Ob n = 6, T2D/WL n = 6. Credit: DOI: 10.1186/s12933-021-01426-z

People with type 2 diabetes have an increased risk of stroke and slower recovery from it. Now, researchers at Karolinska Institutet have shown that neurological recovery from stroke is significantly improved in mice with obesity and diabetes who achieve weight loss to the extent that glucose metabolism returns to normal levels. The results are published in the scientific journal Cardiovascular Diabetology and may have clinical relevance for stroke rehabilitation in type 2 diabetes.

The prevalence of diabetes in the world is expected to rise dramatically to 700 million people in 2045. Stroke is one of the major complications in people with diabetes who are not only at higher of stroke, but also have diminished and slower recovery in the rehabilitation phase. While , including weight loss, can partly reduce the risk of stroke, no study has investigated whether such an approach can also result in a better neurological recovery after stroke.

The results of the study demonstrate the efficacy of weight loss, through a diet intervention, to improve neurological recovery after stroke. Importantly, the weight loss needs to be long lasting and lead to the overall improvement of metabolism, i.e. normalization of glycemia and insulin resistance. A shorter dietary change leading to the same weight loss but not to the improvement of the overall metabolic profile, was ineffective to facilitate neurological recovery after stroke.

“This suggests that people with diabetes might have a better prognosis after a stroke, if will be given a high priority after diabetes is diagnosed,” says Dimitra Karampatsi, MSc and Ph.D. student at the Department of Clinical Science and Education, S?dersjukhuset, Karolinska Institutet (KI S?S) and first author of the study.

The researchers now plan to go ahead and study the association in a clinical registry study.

“This important finding needs to be further explored in to enhance the treatment of our type 2 ,” adds Alexander Zabala, co-author, MD, Ph.D. student at KI S?S and Physician at Vo Acute Internal Medicine and Neurology at S?dersjukhuset.


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More information: Dimitra Karampatsi et al, Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke, Cardiovascular Diabetology (2021). DOI: 10.1186/s12933-021-01426-z

Provided by Karolinska Institutet

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